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مونوسیت بازیابیشده
The second type of recruited monocytes consists of anti-inflammatory monocytes, which have a longer half-life (>2 days, in mice).
They can differentiate from resident progenitor cells, but are more often derived from recruited monocytes from the blood stream.
Specifically, the differing roles of tissue-resident macro- phages and recruited monocytes have become an important area of research because there is accumulating evidence that different monocyte and macrophage populations play distinct and non-redundant roles in tissue repair, fibrosis, and regenera- tion (Gundra et al.
In some cases, the recruited monocytes seed the tissues and adopt a resident macrophage phenotype; however, the mechanisms that restore tissue homeostasis are still under debate.
Because LysM is ex- pressed at high amounts in mature tissue macrophages but is expressed at much lower amounts in recruited monocytes, the conditional mutant provides a tool for distinguishing the contri- butions of resident M(IL-4)-like cells from those of recruited M(IL-4)-like cells.
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